Zn2+-Dependent Single-Stranded DNA Binding and DNA Replication Activities in Replication Protein A
نویسندگان
چکیده
منابع مشابه
Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase.
Human replication protein A (hRPA) is an essential single-stranded-DNA-binding protein that stimulates the activities of multiple DNA replication and repair proteins through physical interaction. To understand DNA binding and its role in hRPA heterologous interaction, we examined the physical structure of hRPA complexes with single-stranded DNA (ssDNA) by scanning transmission electron microsco...
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Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, including DNA replication, repair, recombination, DNA damage response and checkpoint activation, and telomere maintenance. The role of RPA in most of these reactions is to protect the ssDNA until it can be delivered to do...
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ژورنال
عنوان ژورنال: Bulletin of the Korean Chemical Society
سال: 2009
ISSN: 0253-2964
DOI: 10.5012/bkcs.2009.30.12.2867